Rheology of Hyaluronan

The rheology of Hyaluronan (HA) can be expressed by its viscous flow, elastic and pseudoplastic properties. These properties are unique to HA. Though other glycosaminoglycans can also form viscous solutions at considerably greater concentrations, they never form a viscoelastic polymer network. All the properties of HA are dependent on molecular weight, concentration and pH of the solution. In dilute solution, the individual chains entangle and form a continuous network, which makes the system have a pronounced viscoelasticity and pseudoplasticity that is unique for a water-soluble polymer at low concentration. The molecular domains of HA decrease with increasing concentration, and the movement of the molecular chains becomes more restricted, which gives this crowded molecular system viscous and elastic properties.